| 목록구분 | 소장기록 |
|---|---|
| 식별번호 | F-BC-0029 |
| 표제 | Biological Monitoring of Bisphenol A in a Korean Population 2003 |
| 내용 | To conduct proper biological monitoring of environmental exposure to bisphenol A (BPA), the variation in host susceptibility need to be investigated. For this purpose, we studied effects of genetic polymorphism in sulfotransferase (SULT) 1A1 on urinary BPA, a biomarker for BPA exposure, in 73 Koreans (male, 34; female, 39; age, 48.9 ± 11.9 yrs). We used reverse phase-HPLC/FD for analysis of urinary BPA and obtained information from each subject on lifestyle, environment, and potential exposure to BPA via food. The HPLC/FD method showed good reproducibility (CVs < 0.1) and a relatively sensitive detection limit of 0.012 μg/L. These methods yielded a geometric mean of urinary BPA as 9.54 μg/L (8.91 μg/g creatinine), with a geometric standard deviation of 8.32 μg/L. Among potential routes for BPA exposure, only “vinyl wrapping of microwave heating” indicated a borderline positive association with urinary BPA level (p = 0.1). After PCR-RFLP, we found the allele frequencies of SULT1A1*1 and SULT1A1*2 were 0.89 and 0.11, respectively within the subjects. As the SULT1A1*1 allele of SULT1A1 is known to be a rapid sulfonylation-allele, the presence of SULT1A1*1 is suspected to rapidly dispose of environmental BPA. However resultant, urinary BPA levels were not significantly different between theSULT1A1*1/*1 identified subjects and the SULT1A1*1/*2 subjects. Therefore, to clarify host variability in urinary BPA level, different genetic polymorphisms in BPA metabolic enzymes other than SULT1A1 should be further studied. https://blog.naver.com/free5293/220425267062 ※ 저작권 관련으로 원문은 서비스 되지 않습니다. |
| 기록물유형 | 문서류 |
| 기록물형태 | 논문 |
| 원본소장처 | Archives of Environmental Contamination and Toxicology |
| 생산자 | Mihi Yang; Soo-Young Kim; Su-Man Lee; Seong-Sil Chang; Toshihiro Kawamoto; Jae-Yeon Jang; Yoon-Ok Ahn |
| 생산일자 | 2003-05-00 |
| 원본형태 | 전자 |
| 크기분량 | 68.2KB; 6쪽 |
| 언어 | 영어 |
| 관리번호 | 49960 |