| 목록구분 | 소장기록 |
|---|---|
| 식별번호 | F-BC-0025 |
| 표제 | Uncertainties in physiologically based pharmacokinetic models...1999 |
| 내용 | International Archives of Occupational and Environmental Health July 1999, Volume 72, Issue 4, pp 247-254 Uncertainties in physiologically based pharmacokinetic models caused by several input parameters Jae-Yeon Jang, P. O. Droz, Ho Keun Chung Abstract Objective: One of the problems in the application of physiologically based pharmacokinetic (PB-PK) models is that authors often use different input parameters, with unknown influence on the results. Differences in the simulation results obtained with various sets of parameters are examined herein.Method: Chemicals considered were perchloroethylene, toluene, and styrene. Simulations of alveolar concentrations, blood concentrations, and urinary metabolite excretions were performed for the three solvents. The input parameters discussed herein are physiological values, metabolic constants, and partition coefficients. The influence of metabolic constants and partition coefficients is studied by comparison of models against one another. Results: Metabolic parameters such as Vmax and K m varied considerably between authors. Tissue-gas partition coefficients, especially for the fat compartment, also differed according to the authors. Such differences in input parameter values proved to have a large influence on PB-PK model results and, therefore, increased their uncertainties. Uncertainties were much more significant in urinary metabolite concentration than in alveolar and blood concentration for chemicals that are poorly metabolized. On the other hand, uncertainties were more significant in alveolar and blood concentrations than in urinary metabolite excretions for chemicals that are well metabolized. Conclusion: Careful attention is necessary in the selection and/or citation of values from published data. The validity of PB-PK models should be simultaneously confirmed with both the blood and/or alveolar concentration and urinary metabolite concentrations. Received: 22 May 1998 / Accepted: 25 March 1999 https://blog.naver.com/free5293/220425256016 ※ 저작권 관련으로 원문은 서비스 되지 않습니다. |
| 기록물유형 | 문서류 |
| 기록물형태 | 논문 |
| 원본소장처 | International Archives of Occupational and Environmental Health |
| 생산자 | Jae-Yeon Jang; P. O. Droz; Ho Keun Chung |
| 생산일자 | 1999-07-00 |
| 키워드 | |
| 원본형태 | 전자 |
| 크기분량 | 106KB; 8쪽 |
| 언어 | 영어 |
| 관리번호 | 49956 |