| 목록구분 | 소장기록 |
|---|---|
| 식별번호 | F-BC-0022 |
| 표제 | Ethnic differences in biological monitoring of several organic solvents II. A simulation... 1997 |
| 내용 | International Archives of Occupational and Environmental Health November 1997, Volume 70, Issue 1, pp 41-50 Ethnic differences in biological monitoring of several organic solvents II. A simulation study with a physiologically based pharmacokinetic model Jae-Yeon Jang, Pierre O. Droz Abstract To improve the reliability of biological monitoring and the development of biological limit values, ethnic differences in the biological monitoring of several organic solvents were studied in Orientals and Caucasians. Six Caucasian and six Oriental volunteers were exposed to each organic solvent in an exposure chamber for 6 h at rest. The exposure concentrations were 50 ppm for perchloroethylene, 50 ppm for styrene, and 100 ppm for m-xylene, respectively. Experimental results were compared with simulation results of a physiologically based pharmacokinetic (PB-PK) model. Differences between Orientals and Caucasians under occupational exposure were also estimated by extrapolation. The simulation results obtained for the Caucasian group showed good agreement with the experimental results. However, the Oriental group did not show good agreement when the same metabolic parameters values applied to Caucasians were used in the PB-PK model. By modification of the metabolic parameters it was possible to get a good fit between the model and the results of the Oriental group. The simulation results obtained for occupational exposure also showed differences in biological levels between the two ethnic groups. Implications of these differences between experimental and simulation results are discussed in the context of the application of biological monitoring and in the development of biological limit values. Received: 14 October 1996 / Accepted: 29 November 1996 https://blog.naver.com/free5293/220425249399 ※ 저작권 관련으로 원문은 서비스 되지 않습니다. |
| 기록물유형 | 문서류 |
| 기록물형태 | 논문 |
| 원본소장처 | International Archives of Occupational and Environmental Health |
| 생산자 | Jae-Yeon Jang; Pierre O. Droz |
| 생산일자 | 1996-10-14 |
| 키워드 | |
| 원본형태 | 전자 |
| 크기분량 | 1.07MB; 10쪽 |
| 언어 | 영어 |
| 관리번호 | 49953 |